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Sarcopenia, defined by muscle mass, muscle strength and physical performance, was associated with functional decline over a 2-year period in elderly Japanese. Interventions to prevent sarcopenia are very important to prevent functional decline among elderly individuals. Geriatr Gerontol Int 2013; 13: 958�C963. ""To investigate the correlation between handgrip strength and performance of knee flexor and extensor muscles determined using an isokinetic dynamometer in community-dwelling elderly women. This was a cross-sectional study. Sample selection for the study was made by convenience, and 221 (71.07?��?4.93 years) community-dwelling elderly women were included. Knee flexor and extensor muscle performance was measured using an isokinetic dynamometer Biodex System 3 Pro. The isokinetic variables chosen for http://www.selleckchem.com/products/byl719.html http://www.selleckchem.com/products/BEZ235.html analysis were peak torque, peak torque/bodyweight, total work/bodyweight, total work, average power, and agonist/antagonist ratio at the angular velocities of 60��/s and 180��/s. Assessment of handgrip strength was carried out using the Jamar dynamometer. Spearman's correlation coefficient was calculated to identify intervariable correlations. Only knee flexor peak torque (60��/s) and average power (60��/s), and knee extensor peak torque (180��/s) and total work (180��/s) were significantly (P? http://www.selleck.cn/products/gsk-j4-hcl.html elderly women. Geriatr Gerontol Int 2014; 14: 185�C189. Cruz-Jentoft et?al. published a European consensus stating that sarcopenia is a geriatric syndrome characterized by the loss of muscle mass and function.[1] Reduction in muscle mass and especially muscle strength are among the main factors involved in reduction of mobility, and increase in falling risk and disability in the elderly.[2, 3] Forrest et?al. suggested that peak muscle strength was achieved between 20 and 35?years-of-age, incurring a moderate reduction between 35 and 50?years-of-age, with a sharp decline over 65?years-of-age.[4] Multiple interrelated factors contribute to both the development and progression of sarcopenia. It has been postulated that aging is related to a reduction in or a resistance to anabolic skeletal muscle substances, such as serum levels of testosterone and androgens, protein intake, growth hormone, atrophy of type?II fibers, motor unit decline, loss of alpha motor neurons, a sedentary lifestyle, and an increase in plasma levels of acute phase proteins and pro-inflammatory cytokines.[2, 5, 6] In scientific research and clinical practice, instruments such as the handgrip dynamometer and isokinetic dynamometer can be used to assess muscle function.