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A diagnostic algorithm was proposed in order to maximize the diagnostic accuracy of this panel of IHC markers on cell block samples, compared to the histological diagnosis on surgical specimens. A chi-square test was performed to assess the significance of the correlation between the FNAC diagnoses and the corresponding postsurgical histological diagnoses. The Cramer V index was used to measure the strength of the cytology-histology concordance. The specificity (SP), sensitivity (SE), negative and positive predictive values, and diagnostic accuracy rates of all markers under evaluation were calculated http://www.selleckchem.com/products/pirfenidone.html and reported in Table 1, along with the corresponding 95% confidence intervals. The level of significance was set at P = .05. The 103 FNAC samples originally diagnosed as NSCLC-NOS on a morphological ground were categorized into several groups based on the immunoprofile obtained with the markers TTF1, p63, CK5, and CK7 (Figure 1). One group included 46 FNAC cases (44.7%) that were consistent with a diagnosis of SQCC (CK7/TTF1? and CK5/p63+, 9 cases) http://www.selleckchem.com/products/Maraviroc.html or of ADC/LCC (CK7/TTF1+ and CK5/p63?, 37 cases), as confirmed by the corresponding surgical specimen diagnoses: these included all 9 SQCCs, 35 ADCs, and 2 LCCs displaying an immunoprofile consistent with glandular differentiation (TTF1/CK7+) (Cramer V index = 1; P http://www.selleck.cn/products/Paclitaxel(Taxol).html with p40, which is specific for the truncated p63 isoforms present in squamous epithelia. These findings confirmed the role of TTF1 as a strong predictor of glandular phenotype with a high sensitivity (SE = 0.77) and maximum specificity (SP = 1), when squamous carcinoma were compared with nonsquamous cancer (ADC and LCC). Subsequently, after excluding TTF1+ cases, 40 tumors remained, 22 (38.6%) of which were p63+ (any CK5 or CK7), corresponding to a final diagnosis of SQCC and adenosquamous carcinoma in 15 tumors and 1 tumor, respectively (overall 72.