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Measurement of the passive torque�Cangle relations throughout dorsiflexion range is a more precise way to determine tissue stiffness than quantifying the passive range using a single point,12 because passive torque increases more rapidly as the joint is moved towards its maximum range. We found significant differences http://www.selleckchem.com/products/Adrucil(Fluorouracil).html between the two groups in all the passive mechanical properties of the tested ankle; thus, our results lead us to support our experimental prediction. Torques at predetermined joint angles, ankle stiffness (slope of curve), and hysteresis were almost three times as high in the children with CP compared with the typically developing group (p http://en.wikipedia.org/wiki/MERTK of tissue stretch only.16 Even at stretch velocities of 120��/s, only four out of 15 people with spastic hypertonia demonstrated reflex responses in the triceps surae.17 We believe that the sinusoidal movement speed used in this experiment http://www.selleckchem.com/products/SRT1720.html was adequate to measure the passive myotendinous stiffness parameters while not eliciting simultaneous reflex activity. Although the oscillation frequency was significantly different between groups, the children with CP, who were more likely to respond with hyper-reflexia, were stretched at the lower rate, consistent with the subjective need to maintain a relaxed, passive movement. The length of the plantarflexor muscles is difficult to measure in vivo. Therefore, indirect measures of angular displacement in response to applied torque are indicative of the force�Clength variables.10,12 The protocol we used also did not allow differentiation between the mechanical properties of the calf muscle and those of the Achilles tendon and other connective tissues. Nor could we exclude the contribution of other tissues, such as skin, ligament, joint capsule, and cartilage. However, these last structures generally contribute to stiffness only at the end of the dorsiflexion range.