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We calculated scores for the pigmentation signature (mean expression of genes, corrected to baseline) and for TYRP1 (log corrected values), and we found significant correlations between the signature and TYRP1 (rho?=?0.801, P? http://www.selleck.cn/products/VX-770.html score was significantly higher in the group of patients with poorer survival (P? http://www.selleckchem.com/products/INCB18424.html cases (56%), the protein was not detected while mRNA was expressed at high levels, suggesting possible posttranscriptional events. However, when only considering samples with positive immunological staining for TRP1, we found a significant correlation between protein (IHC data) and mRNA (RTqPCR data) expressions (rho?=?0.488, P?=?0.034). In addition, we found that TYRP1 mRNA expression significantly correlated with Breslow thickness and Clark level, confirming that TYRP1 mRNA expression in http://www.selleckchem.com/products/SB-431542.html skin metastases, regardless the lag time to their occurrence, was associated with the main prognosis parameters defined in the corresponding primary lesions. Furthermore, we observed that TYRP1 mRNA levels persisted in successive metastasis biopsies obtained during the course of melanoma progression. Finally, we validated TYRP1 mRNA detection by ISH (n?=?40) and found significant correlation between ISH data and RTqPCR data (rho?=?0.679, P?