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[3] As the authors evaluated perioperative morbidity and mortality outcomes by using propensity score (PS) matching on population-based data, this statistical matching technique seems adequate. Matching was carried out with a set of patients with a body mass index (BMI) ��30 to a control group of patients with a BMI http://www.selleckchem.com/products/CP-673451.html showed significant increases in the rates of wound complications, renal complications and operative times among the obese cohort before PS matching, implicating obesity as a potential predictor of poorer outcomes. Though, after PS matching, there were no observed differences between the two cohorts except https://en.wikipedia.org/wiki/Crotamiton for operative time in a 30-day timeframe. Among tumor extension, tumor dissection and the surgeons' skill, obesity seems feasible to be conducive to prolonged operating time. As mentioned by the authors, the short follow-up time leaves a degree of uncertainty as to whether the results are durable over a longer observation period. As is known, 64% of patients will sustain either methodical or systemic complications within 90 days of radical cystectomy.[5] We therefore agree that those data would be elementary to entirely assess potential surgical complications. http://www.selleckchem.com/products/rxdx-106-cep-40783.html Besides, the implication of established and common surgical complication scores, such as the Clavien�CDindo classification, might have been helpful to objectify the data provided. Nevertheless, as this is the first study defining the perioperative risk by obese patients undergoing radical cystectomy by implementing PS, the authors need to be congratulated for generating new findings in a short follow-up time. Even if the true effect of obesity could still be hard to quantify, these data are vital to the informed consent of obese patients preparing for cystectomy. In general, one will agree that nutritional condition alone cannot be genuinely related to a better or worse outcome after major surgical treatment, but many other factors such as early mobilization, incentive spirometry, early nasogastric tube removal and judicious jejunostomy tube feeding, or total parenteral nutrition usage could lead to reduced morbidity. None declared. ""This is an excellent clinical review of a large number of patients who underwent 21-cores transrectal ultrasound-guided prostate biopsy.