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, 2007). The CNV Discovery Project, undertaken by The Genome Structural Variation Consortium (http://www.sanger.ac.uk/humgen/cnv/42mio/), http://www.selleckchem.com/products/obeticholic-acid.html has used high-resolution array CGH to identify common CNVs, greater than 500 bp, in 20 female CEU HapMap samples and 20 female YRI HapMap samples against a common male reference sample. A total of 42 million probes from 21 2.1 million NimbleGen arrays were tiled across the genome in this experiment (approximately 1 probe per 50 bp) (Roche NimbleGen, Inc., Madison, WI, USA). The normalized intensity data for each probe, in the form of log2 ratios between sample and reference, from this project are freely available in 5 Mb region downloads (http://www.sanger.ac.uk/cgi-bin/humgen/cnv/42mio/downloadBigDB.cgi). In addition, there has been a recent provisional data release of ��validated�� copy number variants (CNVs) called from these normalized data (http://www.sanger.ac.uk/humgen/cnv/42mio/download42miocalls.html). The data made available are the chromosomal start and end coordinates of 8599 CNV events (CNVEs) using NCBI Build 36 positions. Each of these CNVEs has some level of independent validation, either by an independent platform or by overlap with other published datasets. These data were mined for evidence of CNVE in the HIN200 region using the coordinates: chromosome 1:156,950,000 to 157,400,000 of http://www.selleck.cn/products/sch772984.html NCBI Build 36. A selected number of putative CNVs were then typed by array-CGH in 450 HapMap samples. These data are publicly available in the form of integer-value copy numbers indexed by CNV name and HapMap sample ID. The cohort of 50 French male controls used for array CGH was also genotyped on the Illumina Human 1M BeadArray (Illumina, Inc., San Diego, CA, USA). The relationship between SNPs within 100 kb of each of the three putative CNVs at the HIN200 locus was investigated by assessing the correlation (expressed as r2), and also the http://www.selleckchem.com/products/Adriamycin.html statistical significance of this correlation, between the B allele frequency of Illumina SNPs and the log2 fluorescence ratio between sample and reference at the array CGH probes. Quality control statistics and analyses were performed using PLINK (Purcell et al., 2007). SNPs or samples were excluded from analysis using the following criteria: SNPs >10% missing genotype data, samples with >10% missing genotype data, SNPs with >9 Mendel errors (MEs), families with >10 ME, SNPs with MAF