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The laboratory parameters during CVVH therapy of each patient shown in the study were the average of all values during the treatment period. The circuit lifetime was monitored and the patient survival was observed to 60?days. All analyses were performed with the SPSS 11.5 software system (SPSS, Chicago, IL, USA). Continuous data are expressed as median (minimum-maximum) while nominal data are presented as percentages. The Mann-Whitney U or Fisher's exact tests were used to analyze differences between the two modes of anticoagulation http://www.selleckchem.com/products/bay80-6946.html applied whereas Wilcoxon signed-rank test were applied to determine the differences between two time points within each group. The differences were considered significant at P? http://www.selleckchem.com/products/poziotinib-hm781-36b.html patients were on ventilators. These basic patient characteristics for both groups are presented in Table?1. The mean age of patients, the etiology of AKI, severity of illness including APACHE II score and percentages of inotropic drugs were not different between the two groups. The percentages of ventilator usage were 50% and 80% in heparin and citrate groups, respectively. The serum BUN, creatinine, total calcium, ionized calcium, and electrolyte in the two groups were comparable. The baseline serum CRP and MPO levels between both groups were also not significantly different (Table?1). Most of the baseline cytokine levels, except TNF-��, were also comparable between both groups (Table?1). Regarding systemic oxidative stress, the http://en.wikipedia.org/wiki/MYO10 prefilter MPO levels in the heparin group at 6?h were slightly increased from baseline (P?=?0.24) and had returned to baseline levels at 24?h (Table?2). In contradistinction, the prefilter MPO levels at 6?h in the citrate group were significantly lower than baseline values (P?