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The study was approved by the Institutional Review Board of our hospital. All patients were evaluated at 1?month and then at 1�C3-month intervals after treatment. The examination included a PSA measurement and a digital rectal examination. Biochemical recurrence was defined as a PSA level > 0.2?ng/mL in the RRP group and >2.0?ng/mL after nadir PSA in the PPB group. Any case in which the PSA level did not reach http://www.selleckchem.com/products/midostaurin-pkc412.html using the Mann�CWhitney U-test and a ��2 test. The effect of baseline factors, including IPSS, patient's age, method of treatment and ADT on HRQOL after treatment were evaluated using a logistic regression model. Two-tailed P-values https://en.wikipedia.org/wiki/Ketanserin showed no late deterioration, remaining http://www.selleckchem.com/products/liproxstatin-1.html stable up to 36?months (Fig.?1). We have previously reported the trends for general and disease-specific HRQOL until 12?months follow-up.7 In summary, at baseline and 1?month after treatment, the MCS was significantly better in the PPB group than in the RRP group, whereas general HRQOL in the two groups did not differ after 3?months. For disease-specific HRQOL, urinary irritation or obstruction was worse in the PPB group but recovered by 12?months, whereas urinary incontinence was worse in the RRP group and did not recover to baseline. Bowel function and bother showed a transient decline in the PPB group at 3 to 6?months but recovered. Sexual function was worse in the RRP group and did not recover (Figs?2�C6). After 3?years, almost all parameters were the same as the respective scores at 12?months. Urinary incontinence remained a significant problem in the RRP group, showing only a slight and insignificant improvement between 12 and 36?months. Urinary obstruction or irritation for the PPB group had resolved by 12?months and then stabilized. Bowel function and bother were similar in the two groups. Sexual function and bother were unchanged between 12?months and 3?years in both groups.