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At best, single scan phase contrast reduces the total acquisition time by http://www.selleck.cn/products/pfi-2.html a factor of two when compared to phase contrast. In this study, single scan phase contrast is validated against phase contrast in phantom and in vivo. Magn Reson Med, 2011. ? 2011 Wiley-Liss, Inc. ""A chemical shift separation technique for hyperpolarized 13C metabolic imaging with high spatial and temporal resolution was developed. Specifically, a fast three-dimensional pulse sequence and a reconstruction method were implemented to acquire signals from multiple 13C species simultaneously with subsequent separation into individual images. A stack of flyback echo-planar imaging readouts and a set of multiband excitation radiofrequency pulses were designed to spatially modulate aliasing patterns of the acquired metabolite images, which translated the chemical shift separation problem into parallel imaging reconstruction problem. An eight-channel coil array was used for data acquisition and a parallel imaging method based on nonlinear inversion was developed to separate the aliased images. Simultaneous acquisitions of pyruvate and lactate in a phantom study and in vivo rat experiments http://www.selleckchem.com/products/epacadostat-incb024360.html were performed. The results demonstrated successful separation of the metabolite distributions into individual images having high spatial resolution. This method demonstrated the ability to provide accelerated metabolite imaging in hyperpolarized 13C MR using multichannel coils, tailored readout, and specialized RF pulses. Magn Reson Med, 2014. ? 2014 Wiley Periodicals, Inc. ""Due to methodological difficulties related to the small size, variable distribution of hippocampal arteries, and the location of the hippocampus in the proximity of middle cranial fossa, little is known about hippocampal blood flow (HBF). http://www.selleckchem.com/products/MG132.html We have tested the utility of a pulsed arterial spin labeling sequence based on multi-shot true fast imaging in steady precession to measure HBF in 34 normal volunteers (17 women, 17 men, 26�C92 years old). Flow sensitivity to a mild hypercapnic challenge was also examined. Coregistered 3D MPRAGE sequence was used to eliminate from hippocampal and cortical regions of interest all voxel with
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