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Pooled results are presented as risk ratios (RRs) with 95% confidence intervals, in terms of over-prediction (RR > 1) or under-prediction (RR http://www.selleckchem.com/products/MK-1775.html survival in all three groups (low risk, RR 0.98, 95% CI 0.95�C1.00; intermediate risk, RR 1.03, 95% CI 0.99�C1.08; high risk, RR 0.87, 95% CI 0.73�C1.05). The chi-squared trend analysis indicates that, as the trichotomized CAPRA score increases, the probability of survival decreases (P http://www.selleckchem.com/products/AZD6244.html tract (UTUC), results http://www.selleck.cn/products/azd4547.html in loss of a renal unit. Loss of renal function decreases eligibility for systemic chemotherapies and results in decreased overall survival in various malignancies. The study shows that only a small proportion of patients had a preoperative renal function that would allow cisplatin-based chemotherapy. Moreover, eGFR significantly decreased after RNU, thereby lowering the rate of cisplatin eligibility to only 16 and 52% of patients based on the thresholds of 60 and 45?mL/min/1.73?m2, respectively. Taken together with the rest of the literature, the findings of the study support the use of cisplatin-based chemotherapy, when indicated, in the neoadjuvant rather than adjuvant setting. To report (i) the estimated glomerular filtration rate (eGFR) changes in patients undergoing radical nephro-ureterectomy (RNU) for upper tract urothelial carcinoma (UTUC); (ii) the rate of change in eGFR in patients eligible for cisplatin-based chemotherapy; and (iii) the association of preoperative, postoperative and rate of change of renal function variables with survival outcomes. We performed a retrospective analysis of 666 patients treated with RNU for UTUC at seven international institutions from 1994 to 2007. The eGFR was calculated at baseline and at 3�C6 months (Modification of Diet in Renal Disease formula (MDRD) and Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EP) equations).