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Strokes were classified as ischaemic stroke (International Classification of Disease, 10th Revision, code I63), intracerebral haemorrhage (I61), subarachnoid haemorrhage (I60) and unspecified stroke (I64). Information on dates of death was obtained from the Swedish Death Register. Women were followed from 15 September 1997 until the date of first stroke, death (National Death Register) or end of follow-up (31 December 2009), whichever came first. Women were categorized into quartiles of http://www.selleckchem.com/products/z-vad-fmk.html dietary PCB exposure at baseline. Hazard ratios (herein referred to as relative risks or RRs) and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression models with attained age (in years) as the underlying timescale. In the multivariable-adjusted http://www.selleckchem.com/products/ly2157299.html analysis, adjustments were made for education level (12?year), family history of myocardial infarction before the age of 60?years (yes/no), high cholesterol (yes/no), history of hypertension (yes/no), atrial fibrillation before baseline 1997 (yes/no), ever use of postmenopausal hormones (yes/no), use of aspirin (yes/no), smoking status (never, past or current), BMI (0�C4.9, 5.0�C14.9, >15.0?g?day?1), total physical activity (quartiles, MET-hours?day?1), total energy intake (continuous, http://www.selleck.cn/products/s-gsk1349572.html kcal?day?1), consumption of fruits and vegetables (quartiles, servings?week?1), consumption of red and processed meat (quartiles, servings?week?1), consumption of dairy products (quartiles, servings?week?1), dietary MeHg exposure (quartiles, ��g?day?1) and dietary intake of sum EPA and DHA (quartiles, g?day?1). In a separate model, additional adjustments were made for total consumption of high-, medium- and low-fat fish (three categories; no consumers, 1�C3 servings?month?1, and 1 serving?week?1 or more) instead of EPA/DHA. The Schoenfeld's residual test showed no indications of violation of the proportional hazards assumption. Linear trend across categories was tested using median dietary PCB values within categories as a continuous variable. To explore whether factors related to the retention of PCBs in the body modified the stroke risk, stratification by parity (0�C1, 2�C6 children) and BMI (
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