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3 to 30?��M. We are investigating the underlying mechanisms causing this variation in sensitivity to the drug. The expression of some of these genes/proteins affected http://www.selleck.cn/products/JNJ-26481585.html by PLX4720, and their potential relevance for response to different treatments is currently tested in vitro. SMR-P9 Prognostic significance of tumor mitotic rate in T2 melanoma is independent of age J. Baker1, A. Deal2, M. Meyers1, J. Frank2, K. Stitzenberg1, D. Ollila1 1 Division of Surgical Oncology, Department of Surgery, University of North Carolina, Chapel Hill, NC, USA; 2Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA Prior work suggested that tumor mitotic rate (TMR) is an important prognostic variable in melanoma patients under the age of 45, but loses significance with increasing age. We sought to determine the association between age and the prognostic value of TMR in clinically node-negative (CNN) T2 melanoma. A prospective IRB-approved database of cutaneous melanoma patients treated from 9 January 1997 to 3 January 2011 was used to identify patients with CNN T2 melanoma. TMR was reported in mitoses/mm2. Associations were evaluated using Fisher's Exact test. We identified 313 CNN T2 patients. Twenty-four per cent were http://www.selleckchem.com/products/epz-6438.html ��45?yr, 37% 46�C64?yr, and 39%��65?yr. Primary site was head/neck (25%), trunk (37%), and extremity (38%). Nineteen per cent had ulceration, 11% had a positive sentinel node (SN), and 10% recurred. Forty-four per cent of patients had TMR ��1/mm2. TMR ��1/mm2 was significantly associated with recurrence; only 4% of those with TMR http://www.selleckchem.com/products/PD-0325901.html recurrence and 18% of those with TMR ��1/mm2 recurred (P?