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The participants of two studies were Indian, and as indicated in a previous http://www.selleck.cn/products/Bortezomib.html meta-analysis they were categorized as Caucasians (Fan et al., 2011). The number of cases and controls for CT and TT genotypes was reported together in the study by Kim et al. (Kim et al., 2003), which could only be used for dominant-model analysis (T carriers vs. CC). Table 3 shows the results of pooled analyses. Overall, the T allele of TGF��1-509C/T polymorphism was not significantly associated with risk of UDT cancer [OR (95% CI) = 1.14 (0.87�C1.51) for TT vs. CC and Pheterogeneity http://www.selleckchem.com/products/PD-0332991.html Qi et al., 2009) with 661 cases and 1206 controls. A total of eight studies (Zhou et al., 2007; Jin et al., 2007; Zhang et al., 2008; Li et al., 2008; Guan et al., 2009; Lin et al., 2010; Bhayal et al., 2011; Guo et al., 2011) were about the relationship between TGF ��1-509C/T and risk of GC, thus we further analyzed their association in detail. Table 4 shows the results of this subgroup analyses. No association was observed in all subgroup analyses. Between-study heterogeneity existed for TT vs. CC, CT vs. CC, T carriers vs. C carriers and T carriers vs. CC of TGF ��1-509C/T polymorphism. Six studies (Tang et al., 2005; Jin et al., 2007; Zhou et al., 2007; Jin et al., 2008; Li et al., 2008; Guo et al., 2011) were identified as main contributors of the heterogeneity by using a Galbraith plot. Results of re-analyses by excluding those studies were 1.13 (0.83�C1.54) and Pheterogeneity= 0.01 for TT http://www.selleckchem.com/products/Everolimus(RAD001).html vs. CC, 1.02 (0.82�C1.27) and Pheterogeneity= 0.05 for CT vs. TT, 1.00 (0.90�C1.11) and Pheterogeneity= 0.31 for T carriers vs. C carriers, 1.01 (0.80�C1.27) and Pheterogeneity= 0.001 for T carriers vs. CC. Sensitivity analyses indicated that no single study had a substantial influence on the pooled results. Publication biases did not exist by funnel plot and Egger test for all comparisons (Pegger= 0.12 for TT vs. CC, 0.11 for CT vs. TT, 0.20 for T carriers vs. C carriers, 0.05 for T carriers vs. CC and 0.25 for TT vs. C carriers) (Fig. 3). Similar to the TGF ��1-509C/T polymorphism, the numbers of cases and controls for CT and CC genotypes were reported together in the study by Kim et al. (Kim et al., 2003), which could only be used for dominant-model analysis (C carriers vs. TT). Table 5 shows the results of overall as well as subgroup analyses for the TGF ��1+869T/C polymorphism.