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""To compare celiac disease (CD) in older and younger adults and to assess the effects of a gluten-free diet (GFD). Retrospective retrieval of information prospectively entered into a structured database. CD clinic, University and Spedali Civili, Brescia, Italy. Two cohorts were identified (older, Group A, n?=?59, >65; younger, Group B, n?=?1,166, 18�C64), and Group B was subgrouped (B1, n?=?600, 18�C34; B2, n?=?440, 35�C49; and B3, n?=?26, 50�C64). Clinical, serological, and histological characteristics of individuals http://www.selleckchem.com/products/byl719.html with CD studied before and during a GFD. At presentation, weight loss (37% vs 21%, P?=?.005) and dyspepsia (22% vs 12%, P?=?.04) were more frequent in older than younger participants. Incidence at diagnosis of non-Hodgkin's lymphoma (NHL) was much higher in older (5%) than younger participants (0.3%, P?=?.003). Prevalence of osteoporosis was 67% in older and 14% in younger male participants and 70% in older and 9% in younger female participants (P? http://www.selleck.cn/products/gsk-j4-hcl.html t-transglutaminase antibodies were negative in 80% of older and younger participants. Lumbar-sacral and femoral T scores increased significantly during a GFD in pooled results of 48 older and younger participants studied before and during GFD. NHL is already present at CD diagnosis in most cases in individuals aged 50 and older, emphasizing the importance of early diagnosis. Older and younger individuals are equally adherent and equally benefit from a GFD, indicating that older age is not a barrier to dietary treatment. ""To determine the prevalence of cognitive impairment in older adults with heart failure (HF). Cross-sectional analysis of the 2004 wave of the nationally representative Health and Retirement Study linked to 2002 to 2004 Medicare administrative claims. United States, community. Six thousand one hundred eighty-nine individuals aged 67 and older. An algorithm was developed http://www.selleckchem.com/products/BEZ235.html using a combination of self- and proxy report of a heart problem and the presence of one or more Medicare claims in administrative files using standard HF diagnostic codes. On the basis of the algorithm, three categories were created to characterize the likelihood of a HF diagnosis: high or moderate probability of HF, low probability of HF, and no HF. Cognitive function was assessed using a screening measure of cognitive function or according to proxy rating. Age-adjusted prevalence estimates of cognitive impairment were calculated for the three groups. The prevalence of cognitive impairment consistent with dementia in older adults with HF was 15%, and the prevalence of mild cognitive impairment was 24%.