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The purpose of our study was to assess the value of the surface electrocardiogram (ECG) and the electrophysiology study (EPS) as predictors of conduction abnormalities after PAVI. Methods: Twenty seven consecutive pts mean aged 81 �� 6 years with severe aortic stenosis and normal or slightly impaired left ventricular function (mean LVEF 53 �� 10%) who underwent Core Valve-Medtronic implantation were included. The baseline 12-lead surface ECG was analyzed for the recording of basic rhythm and conduction abnormalities. A basic EPS study was performed a day before for https://www.selleckchem.com/products/azd9291.html the measurement of the basic intervals PA, AH, HV, the effective refractory period (ERP) of the atrioventricular (AV) node and the Wenckebach cycle length (WCL). Results: At baseline evaluation 21 pts were in sinus rhythm and 6 in chronic atrial fibrillation. The mean PR and QRS were 185 �� 25 msec and 118 �� 27 msec. Six pts had a LBBB and 3 LAH. The basic EPS measurements were: AH 93 �� 17 msec, HV 51 �� 11 msec (34�C90 msec), AV-ERP 288 �� 59 msec, and WCL 386 �� 72 msec. All pts, except 1, had HV intervals https://www.selleckchem.com/products/ch5424802.html with pre-existing conduction abnormalities revealed in an EPS study may be susceptible to development of complete AV block after PAVI. P072 HIGH PREVALENCE OF AMYLOID DEPOSITION IN SUBCUTANEOUS FAT TISSUE IN PATIENTS WITH BRADYARRHYTHMIA Omi W; Hanaoka R; Takatori O; Saeki T; Kasashima S; Kawashima A; Sakagami S Department of Cardiology, Kanazawa Medical Center, National Hospital Organization Background: Most of cases with amyloidosis progress asymptomatically, and is diagnosed when cardiac involvement is already at end stage. Additionally, the diagnosis is sometimes cumbersome and accompanied with complication. These factors make early diagnosis difficult. Aim: To assess the usefulness of subcutaneous fat sampling during pacemaker implantation and to validate the https://www.selleck.cn/products/Everolimus(RAD001).html prevalence of systemic amyloidosis in patients with bradyarrhythmia who required permanent pacemaker. Patients and Methods: We enrolled 15 consecutive patients (79 �� 12 years old, 7 males) who required pacemaker implantation (containing 4 patients, generator exchange). Four patients had sick sinus syndrome and 11 had atrioventricular block. In all cases, echocardiography did not show typical findings suggesting cardiac amyloidosis. Pacemaker was inserted to infraclavicular precordia. Subcutaneous fat tissues were taken during surgery and specimens were evaluated by the pathologists.