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Only one study described a sample-size calculation (11). http://www.selleckchem.com/products/Maraviroc.html Appropriate statistical tests were described in 10 studies (10�C14,17,19,20,23,24). A wide range of overall rates of DGF were reported by the included studies (13�C73%, Table 3). This may be partly explained by differences in the definitions used for DGF. The most common definition was a requirement for dialysis within the first week after transplantation, used by seven studies (10,12,14,17,19,20,23). Three studies defined DGF as at least two dialysis sessions within the first week (11,13,18) and one study defined it as at least three dialysis sessions within the first week (22). Two studies defined DGF by a lack of immediate urine production (15,16). Two studies did not report DGF as an outcome (21,24). http://www.selleck.cn/products/Paclitaxel(Taxol).html Three RCTs compared UW with Eurocollins solution (EC) including a total of 825 kidneys (11,12,14). These trials had significant differences in their donor populations (1 study used DCD only; Ref. 12) and a large variation in the overall rate of DGF (range 15�C73%). It was, therefore, inappropriate to combine the studies in a meta-analysis. Ploeg et al. conducted a large, good quality, multicenter RCT using a central randomization list to allocate groups (n = 695 kidneys; Ref. 11). They found that EC preserved kidneys had a significantly higher rate of DGF than UW preserved kidneys (RR = 1.46,95% CI 1.15�C1.87, p http://www.selleckchem.com/products/pirfenidone.html There were a large number of unexplained withdrawals postallocation in this study. A central randomization table was used to allocate kidneys to preservation groups. Hefty et al. conducted a smaller, single-center RCT (n = 40 kidneys) finding no difference in the rate of DGF between the two groups (RR = 1,95% CI 0.23�C4.37, p = 1; Ref. 14). The method of randomization was unclear. Two RCTs (13,22) and two non-RCTs (15,16) compared HTK with EC including a total of 783 kidneys. Significant differences between studies in terms of the donor populations (DCD only, Ref. 16); DBD only, Ref. 13), the overall rate of DGF (range 20�C56%) and the definition of DGF prevented meta-analysis. Groenewoud et al. conducted the largest, multicenter RCT using kidney only donors (n = 569 kidneys; Ref. 13). DGF was defined as a requirement for two or more dialysis sessions in the first week postoperatively. The group found that the rate of DGF was significantly higher with EC than HTK stored kidneys (RR = 1.48,95% CI 1.18�C1.85, p