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Results:?Catheter displacement occurred in 3 patients. An increase in postprandial http://www.selleck.cn/products/PLX-4720.html PS activity was observed in patients (P http://www.selleckchem.com/products/avelestat-azd9668.html oliguria (urine output (UO) ��0.5?ml/kg/h) to protect against acute kidney injury (AKI). However, in nephrology a UO ��0.2?ml/kg/h is considered acceptable. We aimed to show that a perioperative UO target ��0.2?ml/kg/has similar effects on renal function as ��0.5?ml/kg/h after major colorectal surgery. Methods:?Patients with eGFR > 60?ml/min/1.73?m2 undergoing elective major colonic surgery were randomised to either a high or low perioperative UO target. Ancillary care was strictly controlled within an enhanced-recovery protocol. Detailed fluid balance and serial plasma creatinine concentrations were collected. The primary endpoint was a well validated biomarker http://www.selleckchem.com/products/a-1331852.html of AKI; urinary neutrophil gelatinase-associated lipocalin (uNGAL) concentration at 8?am on postoperative day 1 (POD1). Results:?41 patients were randomised to the high (n = 18) vs low (n = 23) groups. During the first 48?h, the high group had statistically fewer episodes of oliguria; 9.4 (1.8) vs 21.3 (1.6) (P