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2A). The wound edge of oral mucosa continued to be patent, and epithelial cells extended along the surface of necrotic bone. Along the deep margin of alveolar bone, there was immature bone with numerous cement lines associated with a diffuse, mild, inflammatory infiltrate. Four weeks after tooth extraction, partially necrotic bone fragments or sequestra (sq in http://www.selleckchem.com/products/cb-5083.html Fig. 2B, Table 2) were observed, which were surrounded by inflammatory granulation tissue and were positive for Actinomyces infection (Fig. 2C). Although the wound edge of oral mucosa appeared to close, nonkeratinized oral epithelium grew toward the sequestrum, a lesion consistent with PEH (Fig. 2B, D). Necrotic bone sequestra with PEH seemed to persist in the VitD(?)/ZOL group even 8 weeks after tooth extraction (Fig. 2D). The oral exposure of bone sequestrum appeared to be established by PEH-mediated fistulation. In the control group, the tooth extraction wound showed active osteoclasts within resorption lacunae and lining osteoblastic cells compatible with repair of the maxillary defect (Fig. 2D, Cont). There were sporadic small epithelial inclusions surrounded by multinucleated giant cells (foreign-body type). Compared with the control group, the tooth extraction wound in the VitD(?) group was filled with more immature bone that contained numerous cement lines and osteoclasts and http://www.selleck.cn/products/PD-0332991.html demonstrated extension of the hematopoietic marrow space to near the bone surface (Fig. 2D, VitD(?)). In the ZOL group, new bone in http://www.selleckchem.com/products/a-1155463.html the extraction socket displayed prominent cement lines (Fig. 2D, ZOL). The intervening stroma was cellular and contained scattered inflammatory cells. The histologic specimens taken 4 weeks after tooth extraction from each group were selected for the prevalence study. The ratio of nonvital osteocytes (necrotic bone area) was significantly greater in the buccal alveolar bone of the tooth extraction side than in the unwounded side (p?