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6.?Years on dialysis.? The HCV antibody positivity http://www.selleckchem.com/products/bay80-6946.html rate was lowest for patients treated with dialysis for 5�C20?years (Table?47). The HCV antibody positivity rate suddenly increased after 20?years or more of dialysis treatment. Interestingly, the previous analysis also indicated that the HCV antibody positivity rate suddenly increased after 15?years on dialysis. Because six years have passed since the previous analysis, the patients on dialysis for 15?years or longer in the previous analysis mostly correspond to those on dialysis for 20?years or longer in the present analysis. The findings on the relationship between dialysis years and the HCV antibody positivity rate obtained in the previous and present analyses may include problems related to the measurement of HCV antibody and other issues, and do not necessarily indicate new infection with hepatitis C. For example, the rate of HCV-antibody-positive patients who were started on dialysis before the clinical application of an HCV antibody test and recombinant human erythropoietin and who were treated with dialysis for at least 25?years was as high as 43.3% of those for whom the result http://www.selleckchem.com/products/poziotinib-hm781-36b.html of the HCV antibody test was determined. There is a high possibility that their HCV antibody positivity was not caused by new infection because most of the patients positive for the HCV antibody at a low titer were HCV-RNA-negative. 1.?Fundamental factors.? The risk of HCV antibody positivity was significantly higher in patients fulfilling any of the following criteria: male gender, 60?years or older, on dialysis for 20?years or longer, and having diabetes (Table?48). This finding is in agreement with that on the HCV antibody positivity rate. 2.?Postdialysis weight.? The risk of HCV antibody positivity was significantly lower for patients weighing 60?kg or more after dialysis (Table?49). As reported in the following sections, the risk of HCV antibody positivity was lower in patients with good nutritional status, as determined from various nutritional indices. The finding regarding the patients' weight also suggests a relationship http://en.wikipedia.org/wiki/MYO10 between their nutritional conditions and the risk of HCV antibody positivity. 3.?Predialysis serum creatinine level.? The risk of HCV antibody positivity was significantly higher for patients with a predialysis serum creatinine level of