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Eleven studies evaluated the combination of HBIG with hgbNA(s) [7, 9, 10, 12-14, 16, 18, 19, 22, 25], while eight studies [8, 11, 17-21, 23] evaluated patients under hgbNA(s) after HBIG discontinuation or without any HBIG (Figure 1). There was only one randomized controlled trial [10], while seven were prospective cohort [7, 11, 12, 17, 18, 21, 23] and nine retrospective cohort studies [8, 9, 13, 14, 16, 19, 20, 22, 25]. The outcomes of patients under hgbNA(s) were compared to those of patients under HBIG and LAM from studies (12, 27�C62), which had been http://www.selleckchem.com/products/CP-690550.html included in our previous systematic review [6]. In total, 2214 patients received HBIG and LAM or hgbNA(s) (with or without another NA) as prophylaxis from post-LT HBV recurrence. In particular, monotherapy with LAM was used in 1910 (86%) (12, 27�C62) and with a hgbNA(s) in 304 (14%) patients [7, 9, 10, 12, 14, 16, 18, 19, 22, 25] (Table?1). Patients who received http://www.selleckchem.com/products/XL184.html HBIG and a hgbNA with or without another NA were considered as patients treated with HBIG and a hgbNA and were analyzed together, unless otherwise stated. The characteristics of patients under HBIG and LAM have been described in details in our previous review [6]. Data on the mode and duration of HBIG administration, as well as the dosage and mode of HBIG at anhepatic phase, during the 1st week (day 0 to 7) and during the following 3 weeks (day 8�C30) post-LT were evaluated. Details regarding the mode of HBIG administration were available in 131 patients included in all but four studies [10, 12, 18, 22]: 31 of them received HBIG always intravenously (IV), 97 always intramuscularly (IM) and 3 IV for the first period after LT and IM thereafter. Regarding the duration of HBIG administration, data were available in all but four studies [12, 13, 18, 22] including 160 patients: HBIG prophylaxis was given for a finite duration (median 6 months) after LT in 11% (17/160) of patients (Table?2). In the anhepatic phase, HBIG was given IV in 34 (26%), IM in 93 (71%) or both IV and IM in 4 (3%) of 131 patients with available data [7, 9, 13, 14, 16, 19, 25] and at high (��10?000 U) and low ( http://www.selleck.cn/products/MLN8237.html available data [7, 9, 14, 16, 19, 25]. During the 1st week after LT, HBIG was administered IV in 34 (26%) and IM in 97 (74%) of 131 patients [7, 9, 13, 14, 16, 19, 25], while high dosage of HBIG (��10?000 U/day) was given in 31 (16%) of 194 patients with available such data [7, 9, 14, 16, 19, 22, 25]. Finally, from day 8 to 30, HBIG was given IV in 31 (24%) and IM in 97 (76%) of 128 patients at a median HBIG dose of 1500 (range: 800�C10?000) IU [7, 9, 13, 14, 19, 25].