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5% vs 7.7%, respectively, P? http://www.selleck.cn/products/s-gsk1349572.html transplant is reportedly higher in patients who were transplanted in the presence of PVT compared with those who arrive with patent PVT at LT (19.9% vs 15.3%, P? http://www.selleckchem.com/products/z-vad-fmk.html PVT, 15 (22%) died, compared with 19 (42%) of 45 patients with complete PVT (P?=?0.011) (Table?2). These recent studies understate the need for a clear protocol for the treatment of PVT in patients with cirrhosis, regardless of whether LT might be a future prospect or not. Although it seems fairly clear that patients without PVT at transplant (treated or not) fare better after liver transplant, it is less clear if this is owing solely to the absence of PVT thrombus, or to the lesser severity of liver disease, of which PVT could stand as a surrogate marker. However, not all studies have demonstrated an association between PVT and advanced stage of liver disease [5, 21, 22, 37], and PVT has been identified as an independent factor for negative outcome after liver transplantation (LT). In a nationwide http://www.selleckchem.com/products/ly2157299.html study using data present in the Scientific Registry of Transplant Recipients, PVT was found to be a predictor of post-transplant mortality (HR?=?1.32, P?=?0.02) [24]. In a Japanese study published by Egawa and co-workers, PVT at transplant was associated with a significantly lower MELD score (mean 18.2) when compared to patients with no PVT (mean 21.9), P?=?0.016 [45]. However, this study was performed in a living-donor liver transplantation programme, and results may not necessarily apply to Western, primarily deceased-donor, liver transplantation. Whether it is portal hypertension to weigh on adverse outcomes is not clear, either. However, isolating the variables PVT-portal hypertension is difficult in the clinical practice. It has been demonstrated that recanalization of PVT reduces oesophageal variceal pressure [48], and this alone could contribute to an improvement in morbi-mortality.