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""Vital organ failure remains common in AL amyloidosis. Solid organ transplantation is contentious because of the multisystem nature of this disease and risk of recurrence in the graft. We report outcome among all AL patients evaluated at the UK National Amyloidosis Centre who received solid organ transplants between 1984 and 2009. http://www.selleck.cn/products/azd9291.html Renal, cardiac and liver transplants were performed in 22, 14 and 9 patients respectively, representing http://www.selleckchem.com/products/birinapant-tl32711.html derived. In AL amyloidosis, which has an age-adjusted http://www.selleckchem.com/products/Gemcitabine-Hydrochloride(Gemzar).html incidence in the United States of 5.1�C12.8 million patients per year (1) and is the commonest type of acquired amyloidosis, the fibrils are derived from monoclonal immunoglobulin light chains produced by clonal dyscrasias which are usually of a subtle nature (2). AL amyloid can deposit in almost any organ. Systemic AL amyloidosis may present with dysfunction of a single organ or alternatively, there may be amyloid deposition and dysfunction of multiple organ systems concomitantly. Untreated, it is a progressive and almost universally fatal disease. Deposition of amyloid in the kidneys presents with varying degrees of proteinuric chronic kidney disease (CKD) and may lead to end-stage renal disease (ESRD). In a recent study, 42% of patients presenting with renal AL amyloidosis required renal replacement therapy (RRT) during the course of their disease (3). AL amyloid deposits in the heart typically cause a restrictive cardiomyopathy characterized by concentric ventricular wall thickening and diastolic dysfunction resulting in congestive heart failure (CHF) (4). Once CHF has supervened in AL amyloidosis, prognosis is poor with a median survival of 4�C6 months (5).