The Historical Past For Doxorubicin

046, 95% CI 1.006�C1.087, P?=?0.024) were strong predictors of mortality. This significance persisted after adjusting for etiology of liver disease in the multivariate analysis regarding platelet (HR 0.987, 95% CI 0.980�C0.995, P?=?0.0013) and MELD score (HR 1.076, 95% CI 1.029�C1.124, P?=?0.0012). There was a linear correlation between platelet count and length of survival on the liver transplant waiting list (P?=?0.01). In these analyses, death was considered as the negative outcome, whereas patients who underwent http://www.selleckchem.com/products/obeticholic-acid.html liver transplantation were censored at the time of transplantation. Furthermore, we repeated the analyses using a competing risks technique in which death and orthotopic liver transplantation (OLT) were considered competing events. This did not significantly alter the results (platelet: HR 0.987, P?=?0.003; MELD: HR 1.055, P?=?0.02). Patients with lower platelet counts had significantly higher risk of death on the waiting list. Using platelet count of 100?000/mcL as a cut-off http://www.selleckchem.com/products/Adriamycin.html value, patients with platelet count of less than 100?000/mcL had a mean survival of 935?days in comparison to 1396?days for the group with higher platelet counts (P?=?0.002). At the same time, 21% of the patients with lower platelet count survived without transplantation in contrast to 43% of the group with higher platelet count (P?=?0.0026). Lower platelet count was associated with slightly younger age (50.5 vs. 53.8, P?=?0.011), less cholestatic and alcoholic liver disease (0.9% vs. 11%, P?=?0.003 and 20.2% vs. 37.1%, P?=?0.016, respectively), more viral hepatitis (71.6% vs. 43.1%, P?=?0.0002), smaller liver volume (LVR 0.89 vs. 1.02, P = 0.005), marginally lower albumin (3.14 vs. 3.32, P?=?0.058) and higher MELD (14.61 vs. 12.68, P?=?0.047). Among MELD components, only INR was significantly different between the two groups (1.61 vs. 1.44, P?=?0.006). The group with lower platelet count had a 42.2% death rate on the waiting list in comparison to 23.6% in the group with higher platelet count (P?=?0.01), whereas the percentage of patients receiving liver transplantation was not different between the two groups (36.7% vs. 33.3%, P?=?0.64). http://www.selleck.cn/products/sch772984.html (Table?2) Patients with platelet count higher than 100?000/mcL had a significantly higher rate of event-free survival than patients with lower platelet count (P?=?0.002) (Figs?3 and 4). In a multivariate regression model, low platelet counts (P?