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For injection into the HPLC, FES was eluted from the cartridge into the loop vial which contained 3.5?mL of 0.1?M ammonium formate. FES was collected at 14.5?min after injection and reformulated in saline. Quality control was performed using a Shimadzu HPLC system with a Bioscan BGO detector and a SPD20A detector at a wavelength of 280?nm. Results: FES was synthesised in overall yield of http://www.selleckchem.com/products/cb-5083.html 23?��?5% (n?=?6) with radiochemical purity greater than 95% and specific activity of 1.4?��?0.2 Ci/��mol. The synthesis time including reformulation was 70?min. P55 ROUTINE PRODUCTION OF 68GA-DOTANOC RADIOPHARMACEUTICAL USING AN AUTOMATED MODULAR SYSTEM: THE RAH EXPERIENCE W Hsieh, M Ali, C Tsopelas, D Smyth RAH Radiopharmacy, Nuclear Medicine Department, Royal Adelaide Hospital, Adelaide, Australia Background: Radiolabelled somatostatin analogues of DOTANOC, DOTATOC and DOTATATE are emerging as important diagnostic tracers for the in vivo visualisation http://www.selleck.cn/products/PD-0332991.html of neuroendocrine tumours. Our experience extends to radiolabelling DOTANOC and DOTATATE with 68Ga in the radiopharmacy. During a period when GMP-quality DOTATATE was unavailable, 68Ga-DOTANOC was routinely prepared for neuroendocrine-imaging. Aim: The aim of the study was to share our technical experience regarding the synthesis and quality control of 68Ga-DOTANOC using an automated modular system. Method: Forty six syntheses were carried-out in a GMP-approved, fully automated module (ModularLab; Eckert & Ziegler) comprising a cassette that elutes 68Ga-chloride from a 68Ge/68Ga generator (IGG-100; Eckert & Ziegler) followed by coordination with DOTANOC (ABX) in a reaction vial. On each occasion, a cassette integrity test was performed pre-synthesis, and then a filter integrity test post-synthesis. Similar to the manufacturer-recommended procedure, the reaction was performed at 90oC for 300 seconds in the presence of an acetate buffer (pH 4). After purification and aseptic filtration, the product formulation was quality control tested including % radiochemical purity (RCP) and % radiochemical yield (RCY). During the synthesis and QC process, a dosimeter was worn on the operator's hand. Results: Over a four-month period, the production runs resulted in an average radiosynthesis http://www.selleckchem.com/products/a-1155463.html time of 33 mins and a %RCY?=?78?��?5%. Of the 46 particle-free formulations, 32 were patient doses and 7 were validations. 68Ga-DOTANOC patient doses had %RCP?=?94?��?2%,