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Although the absolute mortality rates differed somewhat by age at transplant, the relative risks of death on dialysis and with retransplant (compared with function of the first transplant), and the pattern of change in mortality risk over time were similar regardless of age at transplant. Standardized mortality ratios:? As illustrated in Figure 3A�CD, compared with individuals of the same age, sex and race in the general population, mortality rates in the first post transplant year of the first graft were between about 15 times higher (in those 16�C21 years old at transplant), and 130 times higher (in those 0�C4 years old at transplant). However, in subsequent years, SMRs for those who maintained function of the first graft were much lower, http://www.selleck.cn/products/azd6738.html and diminished slightly with increasing time since transplant. Differences in SMRs by age at transplant were driven primarily by age-related differences in the expected mortality rates in the general population. SMRs in the first year of a second transplant were generally quite high, but were rather unstable due to the small numbers undergoing a second transplant within any given 1-year http://www.selleckchem.com/products/pf-562271.html interval. In subsequent years of a second transplant, SMRs were only slightly higher than SMRs for those with continuous function of the first graft. Adjusted relative hazards:? The results of the final Cox model estimating the associations between all-cause mortality and each of time since transplant and the treatment status are presented in the first column of Table 2. Preliminary analyses indicated that, compared with function of the first graft (beyond the end of the first year), the first year of return to dialysis was associated with a 4.14 [95% confidence interval (CI) 3.41, 5.02] times higher risk of death��which was not distinguishable from the relative hazard associated with subsequent years of dialysis (4.43 [3.99, 4.91]). Therefore only one dialysis status category was considered in the final model. There was no significant interaction between transplant era and either of time since transplant or status category; therefore, analyses were adjusted for, but not stratified on, era. Adjusting for all other covariates, the risk of death decreased http://www.selleckchem.com/products/VX-765.html by 1%[0%, 3%] per year after the end of the first year of the first transplant, but this was not statistically significant (p = 0.06). Compared with patients with continuous function of the first graft, mortality rates were 4.40 times higher for those of the same age and time since transplant being treated with dialysis following graft failure (p