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Table 1 also showed the quality of the included studies. None of individual study satisfied all the items of validity assessment, so the overall quality was not high. All http://www.selleckchem.com/PD-1-PD-L1.html included studies mentioned ��random,�� or ��randomized�� or ��randomization,�� however, only four studies described methods of randomization in detail (32, 33, 39, 43). No details of allocation concealment and blinding were reported. Two studies reported the loss of follow-up (27, 29), but no intention-to-treat analysis was conducted, and no explanation was given. There was no selective outcome reporting bias in all studies. The sample size varied from 40 to 160 patients. A total of six studies (29, 33, 36, 39�C41) did not compare the baseline conditions http://www.selleckchem.com/products/Adriamycin.html between two groups, so some other source of bias may be presented. Data on complete response (CR) was available in 16 studies (26, 27, 29, 31�C35, 38�C45), which evaluated short-term effects. They were divided into 10 subgroups according to the different chemoradiotherapy regimens, and there was no statistical heterogeneity in all the studies on CR (P = 0.88; I2= 0%). Results of fixed-effect model meta-analysis showed that there was no significant difference on CR between the two groups (RR = 1.42; 95% CI 1.05 to 1.92; P = 0.02; Fig. 2). Quality of life improvement rate (KPS scale) was also evaluated as a primary outcome in 17 studies (26�C28, 32�C45). There was no significant heterogeneity between the two groups in all studies (P = 0.05; I2= 40%). Figure 3 showed that quality of life improvement rate in the IBJOE group was higher than the control group (RR = 1.83; 95% CI 1.63 to 2.07; P http://www.selleck.cn/products/MK-1775.html 46) evaluated the improvement in quality of life with SF-36 scale and the results showed that the IBJOE group had a better quality of life than the control group (MD = 79.46; 95% CI 45.97 to 112.95; P