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The incidence of occurrence of second primary noncutaneous malignancy in Korean NMSC patients were compared to crude incidence rate (CR) of cancer in general Korean population. Among the 350 BCC and 176 SCC patients, there were 19 patients and seven patients diagnosed with a second primary noncutaneous malignancy after the diagnosis of BCC and SCC, respectively. Comparing to the crude incidence rate (CR) of cancer in general Korean population, both SCC and BCC group showed statistically significant increased risk of occurrence of second primary noncutaneous malignancy (P? http://www.selleckchem.com/products/PD-0325901.html risk factor for subsequent malignancies even http://www.selleckchem.com/products/3-methyladenine.html in Korean population where the incidence of NMSC is much lower than Caucasians. 92 Differential expression patterns of MMPs and the role in invasion in epithelial premalignant tumors and invasive squamous cell carcinoma Mi Ryung Roh1,2, Hee Chul Jeung2, Sun-Young Rha2, Kee Yang Chung1 1Department of Dermatology and Cutaneous Biology Research Institute; 2Department of Medical Oncology and Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea Co-expression of several members of the matrix metalloproteinase (MMP) family is characteristic of human malignant tumors. Among the MMPs, MMP-2,-9 and MT1-MMP are thought to be involved in the process of destruction of basement membranes and stromal invasion by neoplastic epithelial cells. In order to investigate the role of MMPs in cutaneous oncogenesis, we compared the expression of MMP-2, MMP-9, and MT1-MMP in epithelial premalignant tumor and invasive squamous cell carcinomas. A total of 25 normal epidermis, 32 Bowen's disease (BD), 62 squamous cell carcinoma (SCC) samples were obtained for the study. MMP-2,-9 and MT1-MMP mRNA were detected by relative quantitative real-time RT-PCR and MMP-2,-9 and MT1-MMP protein was examined by immunohistochemical staining. When compared with normal epithelium and BD, SCC showed statistically significant increase in the expression of MT1-MMP with different expression patterns. SCC showed high expression of MT1-MMP in the invasive front of the tumor, while BD showed higher expression around the tumor cells in the epithelium. SCC http://www.selleck.cn/products/Cisplatin.html also showed higher MMP-2 expression compared to normal epithelium and BD. However, MMP-9 did not show a statistically significant difference. MT1-MMP and MMP-2 mRNA expression in SCC was significantly higher than that in normal epidermis. (P?=?0.03, P?=?0.049) The mRNA expression level correlated with the immunohistochemical staining results. The MT1-MMP, MMP-2 and MMP-9 expression was in accordance with mRNA expression level in SCC. The significantly high level expression of MT1-MMP and MMP-2 in SCC suggest that these proteinases may contribute to the transition from in situ carcinoma to invasive phenotype.