The Disguised Diamond Of Cisplatin

C.-E. Wu1, C.-H. Hsieh1, W.-K. Huang1, C.-J. Chang2, J.-T. Yeh3, T.-T. Kuo4, Y.-F. Lo5, C.-H. Yang6, K.-J. Lin7, J.-J. Hsieh1, H.-Y. Cheng1, J. W.-C. Chang1 1Division of Hematology-Oncology, Chang Gung Memorial Hospital2Department of Plastic Surgery, http://www.selleck.cn/products/Cisplatin.html Chang Gung Memorial Hospital3Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital4Department of Pathology, Chang Gung Memorial Hospital5Department of General Surgery, Chang Gung Memorial Hospital6Department of Dermatology, Chang Gung Memorial Hospital7Department of Medical Imaging and Radiological Sciences, Chang Gung Memorial Hospital, Taoyuan, Taiwan ROC Sentinel lymph node biopsy (SLNB) is the standard management for clinically node-negative cutaneous melanoma patients. The aim of this study was to evaluate the role of SLNB in melanoma patients, and in particular Taiwanese patients with acral lentiginous melanoma (ALM). A total of 465 cutaneous melanoma patients http://www.selleckchem.com/products/PD-0325901.html underwent surgery from January 2000 to December 2011 at Linkou Chang Gung Memorial Hospital. We retrospectively analyzed the clinicopathological characteristics and survival outcomes of these patients who underwent primary surgery followed by either SLNB or observation. Among the 465 patients, 127 underwent SLNB and 51 were observed only after primary surgery. There were no significant differences in clinicopathological features between the two groups except that patients who underwent SLNB were older and had a higher rate of ALM http://www.selleckchem.com/products/3-methyladenine.html than those under observation. The median follow-up time was 43.5?months (to July 2013). The patients who underwent SLNB had significantly better disease-free survival (DFS) (57.1 versus 18.7?months, P?=?0.01) and overall survival (OS) (112.4 versus 45.2?months, P?