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The limited spatial resolution of PET scanners (about 5?mm) is well known, and such scanners are unable to detect lesions smaller than 5?mm. In addition, the partial volume effect might be another reason for failure to http://www.selleckchem.com/products/rxdx-106-cep-40783.html detect small lesions. Although a few groups have shown that increased 11C-choline uptake in primary prostate cancer is correlated with histological surrogate markers of aggressiveness, such as the Gleason Score and MIB-1/Ki-67 labeling index,[52, 59] many groups have failed to find a significant correlation between 11C-choline uptake in primary prostate cancer and the serum PSA levels, Gleason Score or tumor grade.[50, 51, 53, 57, 58] With regard to the detectability of prostate cancer, several groups have shown that conventional morphologic MRI; for example, T2WI alone, was inferior to 11C-choline PET/CT,[55] but that adding DCEI to T2WI showed better sensitivity and specificity than 11C-choline PET/CT (Table?3).[15, 55] Martorana et?al. also reported that the sensitivity of 11C-choline PET/CT for assessment of extraprostatic extension was low in comparison with MRI (22% vs 63%, P? http://www.selleckchem.com/products/CP-673451.html was lower sensitivity for sextants with a small tumor burden, 18F-fluorocholine PET appeared capable of localizing dominant malignant regions https://en.wikipedia.org/wiki/Crotamiton in the prostate.[62] Beheshti et?al. noted a good correlation (r?=?0.68; P?