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There were no severe or serious adverse events; none of the patients discontinued therapy prematurely. In conclusion, the combination of the protease inhibitor BI 201335, the polymerase inhibitor BI 207127, and RBV has rapid and strong activity against HCV genotype 1 and does not cause serious adverse events. In SOUND-C2, 362 treatment-na?ve patients with chronic genotype-1 HCV infections were randomized into five IFN-free treatment arms, each with 120?mg BI 201335 once daily (QD) but with different dosings of BI 207127 and RBV. Tegobuvir http://www.selleckchem.com/products/dabrafenib-gsk2118436.html (GS-9190), a non-nucleoside NS5B polymerase inhibitor, and GS-9256, an NS3 serine protease inhibitor, were developed by Gilead. The antiviral activity of tegobuvir and GS-9256 as oral combination therapy, or together with RBV or PEG-IFN and RBV, was assessed in a phase 2, randomized, open label trial [49]. Treatment-na?ve patients with genotype 1 HCV were assigned 28?days of tegobuvir 40?mg twice daily and GS-9256 75?mg twice daily (n?=?16), tegobuvir and GS-9256 plus RBV 1000�C1200?mg daily (n?=?15), or tegobuvir and GS-9256 plus PEG-IFNalfa-2a/RBV (n?=?15). The primary efficacy endpoint was RVR at Day 28. After 28?days, all patients received PEG-IFN/RBV. Median maximal reductions http://www.selleckchem.com/products/sch772984.html in HCV RNA were �C4.1 log10?IU/ml for tegobuvir/GS-9256, �C5.1?log10?IU/ml for tegobuvir/GS-9256/RBV, and �C5.7?log10?IU/ml for tegobuvir/9256/PEG-IFN/RBV. RVR was observed in 7% (1/15) of patients receiving tegobuvir/GS-9256, 38% (5/13) receiving tegobuvir/GS-9256/RBV, and 100% (14/14) receiving tegobuvir/9256/PEG-IFN/RBV. The addition of PEG-IFN/RBV at Day 28 or earlier resulted in HCV RNA? http://www.selleck.cn/products/ly2157299.html in a Phase 2b, international study of PSI-7977 and PSI-938, two nucleotide analogue polymerase inhibitors for the treatment of HCV. The QUANTUM trial will evaluate IFN-free regimens of PSI-7977 400?mg QD and PSI-938 300?mg QD with and without RBV for 12 or 24?weeks in treatment-na?ve patients with HCV. The trial will also evaluate the use of PSI-938 monotherapy. HCV patients will be stratified by IL-28B status and baseline HCV RNA to ensure balance across cohorts. Patients with and without cirrhosis will be enrolled in this study. An open label phase II study that was launched in 2011 to study the efficacy of the combination of ABT-333, ABT-450/r and RBV (without IFN) to treat chronic hepatitis C genotype 1 treatment-na?ve patient and prior non-responder patients.