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Correlation analysis between the change in FMD and systolic blood pressure and the change in FMD and VO2 peak was performed using Pearson bivariate correlation test. Paired t-tests were used to compare changes in biomarkers and to compare changes in brachial artery diameter and FMD in each group. Patients were approximately 7 years posttransplant and 22% underwent transplant surgery more than 10 years earlier, with no difference between groups (Table 1). The indication for transplantation was ischemic heart disease in 33% and dilated cardiomyopathy in 67%. Patients were all treated with a calcineurin inhibitor and an antiproliferative agent. Corticosteroids were used by 57% in the intervention group and 85% in the control group. Most were overweight, and 89% were treated for hypertension with ACE-inhibitors, angiotensin 2 receptor blockers, dihydropyridine http://www.selleckchem.com/products/pirfenidone.html calcium antagonists or beta-blockers, alone or in combination. Most patients (89%) were treated with a statin. Diabetes was present in five patients (19%) and two (7%) patients were on insulin therapy. One subjects in the exercise group (7%) and four subjects in the control group (31%) had mild to moderate reduced LVEF and the rest had normal LVEF. Measurement of E/E�� was available in 12 of 14 subjects (86%) in the exercise group and in 8 of 13 subjects (62%) in the control group. An E/E�� ratio between 8 and15 suggestive of diastolic dysfunction was found in 5 of 14 subjects (36%) in the exercise http://www.selleck.cn/products/Paclitaxel(Taxol).html group and in 5 of 8 subjects (62%) in the control group. Left ventricular hypertrophy was uncommon in this study and was found only in 1 subject in the exercise group and two subjects in the control group. During the study period no significant change in weight, hip�Cwaist ratio, fasting cholesterol, http://www.selleckchem.com/products/Maraviroc.html fasting triglycerides, fasting serum insulin, fasting plasma glucose or adiponectin was seen in the exercise group or in the time control group (Table 2). In the exercise group systolic blood pressure fell significantly while diastolic blood pressure did not. In the control group no significant changes in blood pressure were seen during the study (Table 2). Peak oxygen uptake was significant increased in the exercise group compared to the control group (p