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Patient with hypogammaglobulinemia at baseline were excluded by this analysis. Serum level of IgG, IgA and IgM were tested at baseline, during the therapy and routinely during follow up period. Results: 18/77 (23%) patients developed SSH after 1 first line therapy with fludarabine based regimens; this value results significantly higher if compared with other regimens (p L. Norasetthada,1 W. Nawarawong,1 A. Lekakul ,2 P. Rujirojindakul ,2 N. Siritanarat ,3 A. Khuhapinant ,3 T. Intragumtornchai,4 U. Bunworasate,4 C. Sirijerachai,5 K. Chansung,5 T. Suwanban,6 S. Chuncharunee,7 P. Nipharuck,7 R. Pornvipavee,8 T. Numbenjapon,9 K. Prayongkatana,9 N. Kanitsap.10 1Internal Medicine, Chiang-Mai University, Chiang Mai, Thailand, 2Internal Medicine, Songklanakarind Hospital, Prince of Songkla University, Songkla, Thailand, 3Internal Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, 4Internal Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand, 5Internal Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand, 6Internal Medicine, Rajvithi Hospital, Ministry of Public Health, Bangkok, Thailand, 7Internal Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 8Internal Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand, 9Internal Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand, 10Internal Medicine, Thammasart Hospital and University, Bangkok, Thailand Background: The prevalence of HIV-seropositivity is 1.3% among Thai populations. The clinical features, and survivals of Thai patients with HIV related lymphoma (HRL) are still lacking. Method: Patients with HRL were collected from the series of 4,308 patients with lymphoma, diagnosed from 2003 �C 2011 at 11 medical centers in Thailand. Results: Of 3,154 patients with known HIV serostatus, 209 patients (6.6%) with HRL were identified. The median age was 39 years (21-78) with a 2:1 male-to-female ratio and a median CD4+ T-cell count of 86 cells/��L. The common histologic subtypes were diffuse large B-cell lymphoma (DLBCL, 69%), Burkitt's lymphoma (11%) and peripheral T-cell lymphoma (7%). Though two thirds of patients had good performance status (ECOG