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�� Among cases, the simple model correctly classified 92% (357 of 389) of cases or 5.8% (357 of 6154) of the entire cohort as ��treat.�� The FRAX model, however, classified 8% (31 of 389) http://www.selleckchem.com/products/a-1155463.html fewer cases or 0.5% (31 of 6154) fewer women as ��treat.�� Among noncases, the simple model classified 66% (3835 of 5843) of noncases or 62% (3835 of 6232) of the entire cohort as ��treat.�� When using the FRAX model instead, 17.7% (1032 of 6232) fewer noncases or 16.6% (1032 of 6232) fewer women were classified as ��treat�� (Table 3). Addition of the FRAX variables to FN BMD and age (simple model) caused 20% (1235 of 6232) of the SOF cohort to change risk categories; the net reclassification was only 9.8%. This was so because the proportion of noncases classified http://www.selleck.cn/products/PD-0332991.html as low risk (correct risk category) was greater than the proportion of cases classified as low risk (incorrect risk category). The overall rate of major osteoporotic fractures was 20% per 10 years of follow-up. The FRAX model and the simple model were both well calibrated (the observed and expected rates of major osteoporotic fracture were similar). The rate of major osteoporotic fracture among those classified as ��treat�� (10-year risk?��?20%) was 37% per 10 years for the FRAX model and 35% for the simple model. The rate of major osteoporotic fracture among those classified as ��no treatment�� (10-year risk? http://www.selleckchem.com/products/cb-5083.html of the high-risk category (��20%). However, among women classified as high risk with the simple model, 36% (780 of 2163) were reclassified as low risk using the FRAX model. The observed 10-year rate of major osteoporotic fracture among these women was 22.6%. This observed fracture rate is higher that the predicted fracture rate of the low-risk category (