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The proportion of cycles leading to hospitalization for toxicity was significantly higher in the VIP-rABVD arm (15% vs. 8%, P?=?0��04). No differences were observed between the two arms in terms of hepatic, renal, cardiac or neurological toxicity. The number of delayed cycles was higher in the VIP-rABVD arm (21% vs. 4%, P? http://www.selleckchem.com/products/SP600125.html treatment plan, the overall response rate (ORR) was 62% (n?=?55/88), including CR in 34 cases (39%) and PR in 21 (24%). Similar responses were observed after VIP-rABVD or CHOP/21 (19 vs. 15 patients were in CR, 6 vs. 15 in PR and 18 vs. 15 were NR; P?=?0��10). Regardless of the treatment arm, the CR rate was significantly higher in ALCL than in other groups (64% for ALCL vs. 53% for AITL vs. 29% for PTCL-nos, P?=?0��04). At a median follow-up time of 110?months (26�C158), 52 (59%) patients had died. The median EFS of the 88 patients was 12?months. The 2-year EFS rate, which was the primary end-point of the study, was 45% (��8%) with VIP-rABVD and 41% (��7%) with CHOP/21; this difference was not statistically significant (P?=?0��70). There was also no significant difference in the 5-year EFS, at 32��5?months for VIP-rABVD versus 32?months for CHOP/21. The median OS was 42?months http://www.selleckchem.com/products/AZD6244.html for both arms. Survival curves of EFS or OS were superimposed for the two arms (Fig?2A, B). For the group of the 61 young patients (below age 60?years) these results were similar without difference for EFS or OS between the two arms. In univariate analysis, three factors predicted a longer EFS and OS duration: CR/PR at the end of treatment, ALCL histological type and Ann-Arbor stage I�CII (Fig?3A, B). Bone marrow involvement was only related to EFS. The IPI score was useful to determine two groups of patients (IPI 0-1 vs. 2�C5) with different EFS (P?=?0��023) (Fig?3C) and OS (P?=?0��03). In a multivariate analysis with a ascendant Cox model, only two factors appeared to be of independent prognostic value for EFS: ALCL (HR: 4��3; 95%CI: 1��32�C13��9; P?=?0��015) and Ann-Arbor stage I�CII (HR: 2��27, 95%CI: 1��02�C5��08; P?=?0��044). Therefore the treatment was http://www.selleck.cn/products/Imatinib(STI571).html forced in this model and did not appear to be an independent factor of EFS (HR: 0��99; 95%CI: 0��58�C1��69; P?=?0��977). Age under 60?years and ALCL type were two independent factors for OS. To date, The GOELAMS LPT95 trial is the first randomized phase III multicentre study reported in newly diagnosed PTCL patients. The aim of this trial was to investigate the impact of a new alternating combination using VIP and reinforced-ABVD, compared to the CHOP/21 regimen.(Gressin et?al, 2000) Analysis of this study��s outcome demonstrates no difference in term of ORR and CR rates between the two treatment arms tested.