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9 mL/min/1.73 m2, the median serum creatinine at diagnosis being 1.2 mg/dL, last stable creatinine was 1.1. The median serum creatinine after treatment was complete was not worse at 1.0, net change of 0.1 mg. Graft loss occurred in 30 cases, of which 10 were death with a functioning graft, 9 attributed to chronic rejection, 5 attributed to malignancy, 2 from other cause and only 1 each from acute rejection/thrombosis/primary disease recurrence. To ascertain if our results were because centers entered cases with less mortality into our survey, we compared the patient survival between our 92 PTLD survey cases, the 72 nonsurvey responders and the remaining 71 cases from the total 235 cases in the master database. As shown in Figure 1, the survey nonresponders showed no significant difference in survival from the responders, p = 0.0944, 1997 being the earliest PTLD reporting year in both sets. However, http://www.selleckchem.com/products/AC-220.html the 71 earlier cases in the master database that we did not send the survey to (earliest PTLD reporting year 1988) had a significantly worse survival (p = 0.0033) compared to the survey nonresponders. We then analyzed the era effect in more detail. Using all 235 cases and dividing era of PTLD into four year segments, the patient survival after PTLD was significantly better in the two more recent eras starting in 1997�C2009 (p http://www.selleckchem.com/products/nutlin-3a.html categorized by the era (1987�C1996 or 1997�C2009). There is a significantly higher risk of dying after developing a PTLD, especially if the PTLD occurred from 1987�C1996, adjusted hazard ratio (AHR) = 6.1. This risk drops 50% if the PTLD occurs in the later years (1997�C2009), AHR = 3.1; however developing a PTLD still has a significantly higher rate of death when compared to the non-PTLD population. In http://www.selleck.cn/products/Romidepsin-FK228.html another Cox model that looked at survival after PTLD (Table 4), patient age at PTLD above 13 and late PTLD were significant for worse patient survival, while more recent year of PTLD predicted a better patient survival. Recipient race and gender did not impact survival. Combined, the above sets of data confirm a significantly improved patient survival after recent PTLD. Finally, we compared the patient and graft survival of patients who had developed PTLD to matched patients without PTLD in a 1:2 ratio. The patients without PTLD had significantly better survival than the PTLD patients: 94 �� 1.2% versus 85 �� 2.5% at 5 years. The hazard ratio was 3.57 for patients with PTLD, p