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Serum iron concentrations and the percentages of transferrin saturation linearly increased (p for trend?=?0.007 to http://www.selleckchem.com/PD-1-PD-L1.html to serum ferritin quartile categories were estimated http://www.selleck.cn/products/MK-1775.html after considering potential confounding factors (Table 5). The overall rates of bone loss in the total femur, femur neck, and trochanter were ?1.14%/year, ?1.17%/year, and ?1.51%/year, respectively, in postmenopausal women, and ?0.27%/year, ?0.34%/year, and ?0.41%/year, respectively, in middle-aged men. After adjustment for potential confounders in base and/or multivariable models, the rates of bone loss in all proximal femur sites in both genders were significantly accelerated in a dose-response manner across increasing ferritin quartile categories. Even after Bonferroni correction was strictly adopted, p values for trend were still significant at the total femur and femur neck in both genders. Consistently, compared with subjects in the lowest ferritin quartile category of each gender, postmenopausal women in the third and highest ferritin quartile category and middle-aged men in the highest ferritin quartile category showed significantly faster bone loss in the total femur and femur neck (p?=?0.023 to http://www.selleckchem.com/products/Adriamycin.html acute-phase reactant20 that can affect bone metabolism, in the multivariable model, statistical significance for the associations between serum ferritin quartile categories and annualized BMD changes persisted at all sites in both genders (p for trend?=?0.001�C0.048). When we investigated the degree of bone loss in subjects who were excluded due to exceptionally high serum ferritin levels (n?=?12), the mean annualized rates of bone loss in the total femur, femur neck, and trochanter were ?2.20%/year, ?2.45%/year, and ?2.05%/year, respectively, in the 2 postmenopausal women and ?0.46%/year, ?0.50%/year, and ?0.