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Results:?38 patients (89% Female (70% http://www.selleckchem.com/products/poziotinib-hm781-36b.html 42 HCA specimens, from either surgical resection (21 laparoscopic, 1 open), wedge or core biopsies (16 total, 3 laparoscopic) were re-classified according to the Bordeaux classification. Multiple subtypes verified the presence of a heterogeneous adenoma group with multiple subtypes; Inflammatory (44%), HNF-1 Alpha (32%) and beta-catenin (24%; 50% biopsy, 50% resection) and unclassifiable (15%). Conclusion:?Literature suggests beta-catenin mutants predispose to malignant change (10�C15% of HCAs transform) and our data verifies the presence of these mutations in HCAs, showing a heterogeneous group of tumours, however further validation required to assess HCA transformation to HCC and if a new diagnostic approach is warranted. Angela Zilm, Markus Troschler, Andrew Lord, Guy Maddern and Harsh Kanhere The Queen Elizabeth Hospital and University of Adel, South Australia Background:?Numerous publications highlighting better outcomes for complex cancer surgery especially oesophagectomy and Whipple's procedure in high volume centres have been published. A case for volume based centralisation has been made on this basis. Aim:?Assess the perioperative outcomes of Whipples procedure and oesphagectomies at a low volume tertiary referral http://www.selleckchem.com/products/ganetespib-sta-9090.html centre. Methodology:?Retrospective analysis of prospective database for patients undergoing a Whipple's procedure and oesophagectomy was undertaken. Demographic and perioperative data was collected. Follow up and survival data was computed. All perioperative and oncological outcomes were noted. Results:?A total of 53 Whipple's procedures and 50 oesphagectomies were undertaken from 2001 to 2012. All 103 cases were included in the analysis. There was no post-operative or in hospital mortality. The anastomotic leak rates and morbidity was comparable to results published from high volume centres. The oncological outcome, margin negative rates and lymph node yield was comparable to results from high volume centres. The median survival http://www.selleck.cn/products/cobimetinib-gdc-0973-rg7420.html for periampullary cancers was 16 months and 5 year survival was 12 %. The 5 year survival for oesophageal carcinoma was 16% with a median survival of 19 months. Conclusions:?Australian low volume tertiary referral centres can achieve outcomes equivalent to high volume centres for complex cancer resections because of organisational and infrastructural similarities along with surgical expertise. Volume alone should not be used to centralise cancer resections in Australia. Actual outcomes need to be analysed and audited. Manju Chandrasegaram, John Chen, Guy Eslick, Wayne Lee and Christopher Worthley Flinders Medical Centre, South Australia Purpose:?There is an increasing trend to portal vein resection and reconstruction at pancreaticoduodenctomy for pancreatic cancer.