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Qualifying studies were identified by a database search of all echocardiograms performed during the study period with the summary codes ��First trimester fetal echocardiogram��, ��Fetal echocardiogram http://www.selleckchem.com/products/cx-5461.html experience, no specific indications for fetal echocardiogram were excluded. However, given practice patterns in the area, those referred for early fetal echocardiograms were considered by obstetricians or maternal�Cfetal specialists to be at http://www.selleck.cn/products/AZD0530.html higher risk of cardiac defects than the general population. As part of our general practice, all early fetal echocardiograms were first attempted with transabdominal imaging, with transvaginal imaging added when a complete study could not be obtained. The protocol for a complete fetal echocardiogram followed recommendations for heart imaging according to the American Society of Echocardiography Guidelines for Fetal Echocardiography.[12] A complete study included imaging of the four-chamber view, left and right outflow tracts noting ��crossing��, and identification of both the ductal and aortic arches. Two-dimensional images of cardiac structures, and color and pulse wave Doppler of all four valves and both great arteries were obtained. Video clips were obtained of two-dimensional and color imaging sweeping inferior to superior from the four-chamber view through the outflow tracts and three-vessel views. Video clips were also obtained of both the aortic and ductal arches. Flow acceleration or regurgitation across any valve, and/or reversal http://www.selleckchem.com/products/forskolin.html of flow in the aorta or ductal arch was noted. Left and right ventricular function was assessed qualitatively. Heart rate, rhythm, and PR interval were determined by analysis of mitral inflow/aortic outflow Doppler. Gestational age was determined by last menstrual period or by ultrasound measurements of fetal biometrics. All women who underwent early fetal echocardiograms were counseled regarding the limitations of early imaging and were recommended to return for comprehensive fetal echocardiogram at greater than 20?weeks of gestation. Maternal medical records were reviewed for genetic and other anatomic diagnoses of the fetus, and indication for fetal echocardiogram referral. Initial and all subsequent fetal echocardiograms were reviewed for accuracy and consistency of diagnoses.
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