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Continuous variables were analyzed using the Wilcoxon sign-rank test or independent sample t-test as appropriate. Unadjusted survival was calculated using Kaplan�CMeier estimates. Multivariate survival models were constructed using logistic regression and proportional hazards modeling with an endpoint of death on the waiting list and censoring at the time of liver transplantation using the method of maximum likelihood estimates. Type one error differences at the 0.05 level or less were considered statistically significant. All statistical tests were two-sided. A total of 253 patients were evaluated at the Liver Transplant Center at BIDMC over the study time period. Of these patients, a total of 181 http://www.selleckchem.com/products/obeticholic-acid.html patients were included in the study after excluding those who met an http://www.selleckchem.com/products/Adriamycin.html exclusion criterion or did not have liver volume determined using CT volumetry. Among the 181 patients included in the study, there were 63 deaths (34.2%), 64 liver transplants (35.4%), and 54 (30.4%) survivals at the last follow up (Fig.?1). The patients in this cohort were predominantly male (70.7%), suffered from chronic viral hepatitis (60.2%), had a mean age of 51.8?years (SD 8.7), a mean MELD score of 14 (SD 6.4), and a mean platelet count of 103?000/mcL (SD 66?000) at the time of the liver volumetric assessment. The mean LVR was 0.96 (SD 0.31). (Table?1) The rate of death and transplantation rapidly increased over the first 2.5?years on the waiting list and at a 10-year time interval only 30.3% of the patients were alive without transplantation (Fig.?2). The cause of death was liver related in 85.9% of the cases (liver failure, variceal bleeding, and http://www.selleck.cn/products/sch772984.html hepatocellular carcinoma). In 3.5% of the cases, the death was not liver related (lung cancer and lymphoma), 8.8% (unknown) and 1.7% was due to motor vehicle accident. Patients who died on the waiting list had a significantly lower platelet count (104?000 vs. 116?000 per mcl, P?