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4, for variants with minor allele frequency equal to 0.43, such as the rs9939609 variant. Nonparametric one-way analysis of variance was used to test differences among the three genotypes for each clinical and biochemical parameters. Normality of the data was evaluated using the Kolmogorov�CSmirnov test. Mean BMI-SDS in the obese group was similar between the three genotypes (Table 1). The distribution of rs9939609 allele (A and T) frequencies between patients and controls is shown in Table 2. The predisposing A allele was present in 55% of the patients�� and in 43% of controls�� chromosomes. The distribution of heterozygotes was similar between patients and controls (47%), while the distribution of homozygotes for the susceptibility http://www.selleckchem.com/PD-1-PD-L1.html allele A, was significantly higher in patients (31% vs. 20%, respectively) (Table 2). Logistic regression analysis on the http://www.selleck.cn/products/MK-1775.html genotypes yielded a ��2 of 35.5 with an odds ratio of 1.6 (CI = 1.3�C1.8), P http://www.selleckchem.com/products/Adriamycin.html et al., 2008; T?njes et al., 2008; Villalobos-Compar��n et al., 2008; Xi et al., 2010), and clearly show that a group of individuals carefully selected for the phenotype is much more informative than a general population. In fact, in our cohort, we found an OR of 1.6, supported by a statistical significance stronger than that previously reported in most association studies performed in case/control groups of comparable size (Hotta et al., 2008; Kring et al., 2008; Xi et al., 2010). Calculation of statistical power demonstrated the ability of the dataset used for this study to reveal genetic effects with an OR even lower than that actually found. It is worth noting that the distribution of heterozygotes is almost superimposable between patients and controls. In previous reports, data were analyzed either by pooling heterozygotes with AA (Cecil et al., 2008; Zimmermann et al., 2009), or with TT homozygotes (Kring et al., 2008; Hakanen et al., 2009), indicating that the mode of transmission was not clearly defined.