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There are no studies examining the cortical mechanisms responsible for suppression specifically in intermittent exotropia. Many studies of suppression in binocular http://www.selleckchem.com/products/AZD1152-HQPA.html rivalry have not yet produced a consensus regarding where in the visual pathway images are suppressed, or which cortical areas are involved in this process. It has been proposed that anomalous retinal correspondence in constant strabismus reflects a remapping of the deviated eye onto primary visual cortex.1 It has also been suggested that sensory shifts in retinal correspondence can occur in normal human subjects.66�C68 In animals with normal visual experience, binocular neurons in primary visual cortex receive inputs from similar regions in the two retinas, with only relatively small ( http://en.wikipedia.org/wiki/MRIP is more common for smaller http://www.selleckchem.com/products/pf-06463922.html angles of deviation, for which the retinotopic distance necessary to achieve harmonious anomalous correspondence can be spanned by the axonal arbours of two V1 neurons. However, McCormack,72 using visual evoked potential topographic mapping in six strabismic patients, found no evidence for this remapping. In intermittent exotropia, retinal correspondence can shift dynamically from normal to anomalous as the eyes exodeviate. There is no evidence for such plasticity in the binocular inputs of neurons in early visual cortex, so it is not clear whether altered V1 receptive fields can underlie anomalous retinal correspondence in intermittent exotropia. An intriguing possibility is that this form of dynamic retinal correspondence may be mediated by head-centric, not retino-centric disparity mechanisms.73 This is a form of stereo vision which has been proposed on theoretical grounds74 and recently demonstrated in control observers.75 In this form of stereo vision, retinal images are first converted to a headcentric visual direction based on the current direction of the eye��s optic axis, and then the intersection of these headcentric directions are used to compute the object��s position in space.