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[11, 12] Our data show that the preserved kidney volume adjusted for BSA represents an independent predictor of donor renal function at 1 year. This finding is consistent with a previous report by Jean et?al., who found that lower preoperative remaining kidney volume adjusted for BSA was correlated with donor delayed renal function recovery at 6 months post-surgery.[8] In the current study, the preserved kidney volume ratio does not correlate with overall donor renal function at follow up. Therefore, to protect donor renal function, it might be more appropriate to consider the preserved kidney volume adjusted to BSA rather than the split kidney volume. The average decrease in the eGFR in the present study was 30?mL/min/1.73?m2, http://www.selleckchem.com/products/gsk2126458.html which is similar to the pooled average decrease of 26?mL/min/1.73?m2 (range 8�C50) reported by Garg et?al. in their systematic review.[1] The cut-off of http://www.selleckchem.com/products/bay-57-1293.html definition of CKD3 after renal donation was used to define impaired renal function.[10] However the definition of CKD after renal donation is controversial. Barri et?al. stated that the high rate of CKD3 after kidney donation might be an ��artifact�� because of the definition of CKD depending on GFR levels, and does not consider other factors such as the cause of CKD or age.[13] The present study carried a few limitations. First, the retrospective design, which is known to be associated with bias. There is no standardized method to measure renal volume.[7, 8] Two CT-based methods have been suggested, the prolate ellipsoid formula (volume?=?length?��?width?��?thickness?��?[��/6]) http://www.selleck.cn/products/CAL-101.html or the voxel-count method,[7] which was used in the present study. Some reports showed that the voxel method was more accurate and had low interobserver variability.[8] The voxel method might include some non-functional kidney tissue. However, the measurement of kidney weight after nephrectomy also includes these non-functional kidney tissues as well. Another limitation was that renal function was evaluated by the MDRD formula. This method was preferred, as it is commonly used in clinical practice. However, previous studies have shown that estimated GFR was not accurate for subjects with normal renal function. The MDRD formula can underestimate GFR by between 9 and 29?mL/min in a kidney donor population.[14-16] Also, the lack of long-term follow up in the present study represents an additional limitation, as other risk factors, such as cardiovascular events, are not considered. Despite the aforementioned limitations, the present analysis adds to the current literature by suggesting a role of the preserved kidney volume in predicting the donor post-donation renal outcome.