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The study population was composed of 2137 (1442 men, 695 women).26 All 1181 subjects http://www.selleck.cn/products/Methazolastone.html with a first myocardial infarction (920 men, 261 women) had undergone coronary angiography and left ventriculography. The diagnosis of myocardial infarction was based on typical electrocardiographic changes (ST-segment elevation and Q-wave) and increases in the serum activities of enzymes such as creatine kinase, aspartate aminotransferase and lactate dehydrogenase, and in the serum concentration of troponin T. The diagnosis was confirmed by the presence of a wall motion abnormality on left ventriculography and identification, by coronary angiography, of the responsible stenosis in any of the major coronary arteries or in the left main trunk. The control subjects comprised 956 individuals (522 men, 434 women). They had no history of congenital heart disease, peripheral arterial occlusive disease or http://www.selleckchem.com/products/ABT-737.html other atherosclerotic diseases; of ischemic or hemorrhagic stroke or other cerebral diseases; or of other thrombotic, embolic or hemorrhagic disorders. Multivariate logistic regression analysis with adjustment for age, gender, BMI, and prevalence of smoking, hypertension, hypercholesterolemia, and T2DM showed that the mitochondrial haplogroup N9b was significantly associated with resistance against myocardial infarction in all subjects (P?=?0.0019) with an OR of 0.30 (95% CI 0.14�C0.64), and in men (P?=?0.0007) with an OR of 0.20 (95% CI 0.09�C0.52), as shown in Table?4, on the basis of a P value of http://www.selleckchem.com/products/Nutlin-3.html were associated with myocardial infarction.51 We examined whether these nuclear polymorphisms were related to mitochondrial haplogroup N9b. The ��2-tests showed no relationship between haplogroup N9b and these nuclear SNP. Therefore, these results indicate that haplogroup N9b and these nuclear SNP were independent of each other. Mitochondrial haplogroup N9b is characterized by four polymorphisms (m.10607, m.11016, m.13183 and m.14893). Although this haplogroup is too scarce to be detected in southern China and Korea, it is most abundant in the Japanese (2.13%), including the indigenous Ryukyans (2%) and Ainu (2%).