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Dimou,5 C. Galani,2 H. Sinni,2 M. C. Kyrtsonis,5 M. P. Siakantaris,5 V. Pappa,1 E. D. Ioannidou,1 M. Kaparou,4 K. Zervas,3 H. Papadaki,4 P. Panayiotidis,5 N. Constantinou,3 J. Meletis,2 G. Pangalis,6 T. P. Vassilakopoulos.2 12nd Department of Internal Medicine, Propaedeutic, Hematology Unit, General University Hospital "" Attikon"" , Haidari, Greece, 2Department of Hematology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece, 3Department of Hematology, Theagenion Hospital, Thessaloniki, Greece, 4Department of Hematology, University http://www.selleckchem.com/products/MK-2206.html of Crete, Heraclion, Crete, Greece, 51st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece, 6Department of Hematology, Athens Medical Center, Athens, Greece Introduction: The International prognostic index (IPI) is used in R-CHOP treated DLBCL patients (pts) with minor modifications. LDH is evaluated as either normal or abnormal, without considering the degree of elevation. The importance http://www.selleckchem.com/products/ABT-263.html of further LDH grading in DLBCL under R-CHOP has not been previously investigated. Aim: To evaluate the prognostic significance of LDH grading in a multicentre cohort of DLBCL pts who received R-CHOP or similar chemotherapy (CT). Patients and Methods: 641 pts who received R-CHOP or similar CT in 6 centers were evaluated regarding Freedom From Progression (FFP). Toxic deaths were considered as events but unrelated deaths in 1st remission were censored. LDH levels were expressed as multiples of the upper normal limit. Results: Median LDH levels were 1.03x (IQR: 0.72x-1.71x). Pts with normal LDH, 1-1.25x, 1.25-1.5x, 1.5-1.75x, 1.75-2x, 2-3x, 3-4x, 4-5x and >5x were 49%, 14%, 8%, 5%, 3%, 12%, 5%, 2% and 3% of the total population. 7-year FFP in pts with LDH levels within the 2 groups of normal LDH (3x, 7-year FFP ranged between 27 and 40%. Overall, http://www.selleck.cn/products/Erlotinib-Hydrochloride.html 7-year FFP in pts with LDH 3x was 77%, 56% and 37% (p3x was 2.55 (95% CI 1.56-4.16, p