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If the result of the heterogeneity test was P > 0.1, ORs were pooled according to the fixed-effects model (the Mantel�CHaenszel model). Otherwise the random-effects model (the DerSimonian�CLaird model) was used. Meta-regression analysis was conducted to explore heterogeneity. http://www.selleck.cn/products/bmn-673.html This meta-regression analysis examined the effect of certain variables, including HWE in controls (cases or all subjects), genotyping method, the number of cases (controls or all subjects), mean age of cases (or controls) and ethnicity. The potential publication bias was estimated using Begg's test and Egger's linear regression test by visual inspection of the funnel plot, and P http://www.selleckchem.com/products/Everolimus(RAD001).html on pre-existing hypertension in the PE cases. In four papers for the M235T polymorphism, http://www.selleckchem.com/products/PD-0332991.html the results were based on two different populations (Ward et al., 1993; Guo et al., 1997; Curnow et al., 2000; Jenkins et al., 2008); we considered these populations separately in the meta-analysis. Finally, 31 (in 27 articles involving 2555 patients and 6114 controls) and six studies (in six articles involving 681 patients and 2076 controls), respectively, were considered for the meta-analysis on the AGT M235T and T174M polymorphisms (Table 1). One study of the M235T polymorphism (Curnow et al., 2000) was included in the meta-analysis only under the additive model because only allele counts were available from it. Wang et al. (2006) miswrote the 235M allele for the 235T allele in Table 2 of their report and we corrected it in this study. Ward et al. (1993), Romi et al. (1997), Procopciuc et al. (2002) and Kim et al. (2004) did not mention the case definitions they had used. Li et al. (1999) recruited pregnant women with severe PE [PE with a blood pressure of ��160/110 mmHg, and/or more than 2000 mg/24 h (or 2+ dipstick) of proteinuria] as cases. In the study of Zhang et al.