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Nevertheless, new ablation techniques including superior vena cava (SVC) isolation have demonstrated higher success rates. Objective: To determine the incidence of SVC electrical activity in patients elegible for pulmonary vein isolation (PVI) as a methodological approach to understand atrial fibrillation (AF) pathophisiology in a huge cohort of patients. Method: Single-center analysis of consecutive patients who underwent pulmonary vein isolation ablation between may 2009 and january 2011. Electrical activity in SVC was assessed by placing a circular multipolar catheter (Optima, St. Jude medical) inside the vessel. The SVC electrical activity was defined as the registry of potentials inside this structure (impulse conduction between right atrium and SVC) as far as 5 cm by the Optima catheter during sinus rhythm or AF. Results: A total of 107 patients were included. Electrical activity in http://www.selleckchem.com/products/a-1155463.html SVC was assessed in only 42 patients; 90.47% male; Mean age 48 �� 8,4 years; 73.80% presented as paroxysmal AF. A total of 16 patients (38.09%) showed SVC electrical activity. Conclusion: This study confirms a high prevalence, almost 40%, of SVC electrical activity in patients referred for PVI. If this finding become in a new goal in AF treatment has to be determine in future trials. P039 PREVALENCE, CHARACTERISTICS AND PREDICTORS OF PULMONARY VEIN NARROWING AFTER PVAC ABLATION De Greef Y; Tavernier R; Raeymaeckers S; Schwagten B; Desurgeloose http://www.selleckchem.com/products/cb-5083.html D; De Keulenaer G; Stockman D; Duytschaever M Department of Cardiology, Antwerp Cardiovascular Institute Middelheim, Belgium Background: The risk and determinants of pulmonary vein narrowing (PVN) after pulmonary vein isolation (PVI) using a novel multi-electrode http://www.selleck.cn/products/PD-0332991.html ablation catheter (PVAC) are unknown. Methods and Results: PV diameters (PVD) and left atrial (LA) volume were compared by computed tomography before and 3 months after PVI using duty-cycled phased RF energy (2:1 or 4:1 bipolar/unipolar ratio) in 50 patients. PVD was measured in a coronal and axial view at three levels (A = ostium, B = 1cm more distal, C = 2cm more distal). Moderate PVN was defined as a PVD reduction of 25�C50%, severe PVN as > 50%. Axial PVD shortened by 17 �� 16%, 14 �� 16% and 8 �� 22% at level A, B and C respectively (p