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Age-adjusted mortality from coronary heart disease was twice as high for the highest than for the lowest LDL-cholesterol category for men, whilst there was no such association for women (Table?2). Adjustment for potential http://www.selleckchem.com/products/cb-5083.html confounding factors did not alter these associations materially. The multivariable HR (95% CI) of coronary heart disease mortality for the highest versus the lowest concentrations of LDL-cholesterol was 2.06(1.34�C3.17), P?=?0.001, for men and 1.16(0.64�C2.12), P?=?0.62, for women. The corresponding multivariable HR (95% CI) associated with a 1 SD increment in LDL-cholesterol was 1.27(1.13�C1.43), P? http://www.selleckchem.com/products/a-1155463.html did not alter substantially after the exclusion of persons with hypertriglyceridaemia, persons who used lipid lowering medication or deaths within the first 2?years, for analysis with the time-dependent covariates Cox proportional hazard model or for analysis with proportional hazard model for the subdistribution of competing risks (not shown in the table). The HR (95% CI) of coronary heart disease mortality for the highest versus lowest LDL-cholesterol levels was 2.05(1.33�C3.15), P?=?0.001 for men and 1.16(0.64�C2.10), P?=?0.64 for women after the exclusion of persons with hypertriglyceridaemia, 2.22(1.43�C3.46), P?=?0.0004 for men and 1.09(0.60�C1.99), P?=?0.78 for women after the exclusion of persons who used lipid lowering medication, 2.16(1.35�C3.45), P?=?0.001 for men and 1.29(0.67�C2.46), P?=?0.44 http://www.selleck.cn/products/PD-0332991.html for women after excluding deaths within the first 2?years, 1.55(1.02�C2.34), P?=?0.04 for men and 1.01(0.58�C1.76), P?=?0.97 for women, when we used the Cox proportional hazard model with time-dependent covariates and 1.82(1.20�C2.76), P?=?0.005 for men and 1.11(0.62�C1.99), P?=?0.72 for women when we used proportional hazard model for the subdistribution of competing risks. To examine a potential effect modification by menopausal status, we conducted age-stratified analysis (aged