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Methods: Patients were randomized into three groups (n=40 each). Group M received magnesium sulfate 50?mg/kg intravenously (i.v.), followed by 25?mg/kg/h i.v., group L received lidocaine 2?mg/kg i.v., followed by 2?mg/kg/h i.v., and group P received saline i.v. Bolus doses were given over 15?min before induction of anesthesia, followed by an i.v. infusion through the end of surgery. Intraoperative fentanyl consumption and averaged end-tidal sevoflurane concentration were recorded. Abdominal and shoulder pain were evaluated up to 24?h using a visual analog scale (VAS). Morphine consumption was recorded at 2 and 24?h, together with quality of sleep http://www.selleckchem.com/products/SB-431542.html and time of first flatus. Results: Lidocaine or magnesium reduced anesthetic requirements (P http://www.selleckchem.com/products/INCB18424.html improved post-operative analgesia and reduced intraoperative and post-operative opioid requirements in patients undergoing LC. The improvement of quality of recovery might facilitate rapid hospital discharge. ""Myocardial ischemic damage is reduced by volatile anaesthetics in patients undergoing low-risk coronary artery bypass graft surgery; few and discordant http://www.selleck.cn/products/VX-770.html results exist in other settings. We therefore performed a randomised controlled trial (sevoflurane vs. propofol) to compare cardiac troponin release in patients with coronary disease undergoing mitral surgery. Patients with coronary artery disease undergoing mitral surgery were randomly allocated to receive either sevoflurane (50 patients) or propofol (50 patients) as main hypnotic. The primary endpoint of the study was peak post-operative cardiac troponin release defined as the maximum value among the post-operative values measured at intensive care unit arrival, 4?h later, on the first and second post-operative day. There was no significant difference in post-operative peak troponin release, the median (25th�C75th percentiles) values being 14.9 (10.1�C22.1)?ng/ml and 14.5 (8.8�C17.6)?ng/ml in the sevoflurane and propofol groups, respectively (P?=?0.4). Fentanyl administration was different between the two groups: 1347?��?447?��g in patients receiving sevoflurane and 1670?��?469?��g in those receiving propofol, P?=?0.002.