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01?(0.01)?N/g (P http://www.selleckchem.com/products/MK-1775.html to 0.03?[0.015]?N/g, P http://www.selleck.cn/products/azd4547.html The difference in contractile amplitude between the two age groups was significant at the highest concentration of 50?��m imatinib mesylate (two-way anova, P http://www.selleckchem.com/products/AZD6244.html whether the prostate smooth muscle cells were still viable after imatinib mesylate incubation. In the absence of imatinib, the contractile frequencies and AUC were significantly augmented in the young (phenylephrine: n = 8; K+: n = 6) and ageing guinea-pig prostate (phenylephrine: n = 8; K+: n = 9). Although spontaneous contractions were significantly suppressed after 60?min exposure to 1?��m imatinib, this was not seen in responses to phenylephrine and high K+ in both young (phenylephrine: n = 7; K+: n = 5) and ageing guinea-pigs (phenylephrine: n = 8; K+: n = 9), where contractile responses were similar to contractions without imatinib (Fig.?4). Slow-wave frequency was enhanced with the application of phenylephrine and high K+ in both young (phenylephrine: n = 15; K+: n = 7) and ageing guinea-pig prostates (phenylephrine: n = 11; K+: n = 6) but similar to contractions in the presence of imatinib mesylate, these responses were not significantly different to responses in the absence of imatinib in both age groups.