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Materials and Methods: This is a part of the Hong Kong Osteoporosis Study. 1,525 community-dwelling, treatment-naive Southern Chinese men aged 50 or above were recruited. Baseline demographic characteristics and clinical risk factors were obtained, and BMD at the spine and hip were measured. Subjects were prospectively followed for incident low trauma fractures. Ten-year risks of major osteoporotic fracture and hip fracture were calculated using Cox proportional hazards models. Results: The mean age of subjects was 68 �� 10 years. After 3.5 �� 3 (1-14) years of follow-up, 36 non-traumatic incident fractures were reported. The incident rates http://www.selleckchem.com/products/Everolimus(RAD001).html for osteoporotic fractures and hip fractures were 676/100,000 and 132/100,000 person-years respectively. The most significant predictors of osteoporotic fracture were history of fall (odds ratio 14.5) and fragility fracture (odds ratio 4.4). Other predictive factors included outdoor activity http://www.selleckchem.com/products/PD-0332991.html use of walking aid, and age �� 65 years. Each SD reduction in BMD at spine or hip was associated with 1.7 to 2.6-fold increase in fracture risk. Subjects with 5 or more clinical risk factors had an absolute 10-year risk of osteoporotic fracture of 6.2%, which increased to 18.2% if they also had total hip BMD T-score �� -2.5. Addition of BMD information (total hip T-score �� -2.5) significantly enhanced fracture risk prediction when compared to clinical risk factors only (omnibus test p=0.001). Men with multiple risk http://www.selleck.cn/products/Bortezomib.html factors and low BMD T-scores have a higher absolute fracture risk, while men with no risk factors and normal BMD have a lower fracture risk than that predicted by FRAX. Conclusions: Clinical risk factors are population specific and the addition of BMD measurement to risk factor assessment improves fracture risk prediction in Southern Chinese men. Disclosures: Cora Bow, None. SA0335 Clinical Utility of Combined Femoral Neck and Lumbar Spine Bone Mineral Density Measurements in the Individualized Prognosis of Fracture.Tuan Nguyen*1, Nguyen Nguyen1, Steven Frost2, Dana Bliuc1, Jacqueline Center1, John Eisman1. 1Garvan Institute of Medical Research, Australia, 2University of Western Sydney, Australia Femoral neck bone mineral density (FNBMD) has been used as the principal predictor of fracture risk in men and women, even though more than 50% of women and ?70% of men who fracture do not have low FNBMD. Lumbar spine BMD (LSBMD) has also been used in the prognosis of fracture risk, but there is a concern over its predictive value due to degenerative change that affects spinal BMD measurement. The present study sought to address that question by examining the contribution of FNBMD and LSBMD to the prediction of fracture.